While there are three wineries located in the southern part of the state between Charleston and Savannah, most of South Carolina’s wineries are located in the northern part of the state. South Carolina wineries, regardless of their location, must contend with the state’s difficult growing conditions to include high temperatures, high humidity, and fall hurricanes. Fruit wine as well as Muscadine, French-American hybrids, and vinifera are all being experimented with in an effort to find the varieties best suited for South Carolina’s climate. Scroll down to see our comprehensive list of South Carolina wineries and click “map view” to access our advanced winery search. Whether you would like to visit a South Carolina winery that provides food on-site to complement its wines or hosts vineyard weddings, we make it easy to find the best South Carolina wine tour and wine tasting destinations.